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Author: Paro Anand
Total Pages: 100
Release: 2003
Genre: Children's stories, Indic (English)
Rating: 4./5 ( downloads)

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This Book Is Entirely A Work Of Fiction. All Of The Characters, Events And Places Are Fictitious, And Any Resemblance To Places, Events Or Persons, Living Or Dead Is Purely Coincidental And Unintentional.

Download Wingless Flights PDF

Wingless Flights

Author: Danny Miller
Publsiher: Popular Press
Total Pages: 208
Release: 1996
Genre: American fiction
Rating: 4./5 ( downloads)

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Focusing on three major phases in writing about Southern Appalachian mountain people, this study surveys some of the images and depictions of mountain women from the 1880s to the 1950s, in the writings of Mary Noailles Murfree, Edith Summers Kelley, Anne W. Armstrong, Emma Bell Miles, Jesse Stuart, James Still and Harriette Arnow. The two major aims of the study are: to show changes in the descriptions of mountain women - from non-native to native depictions, from romantic to realistic presentations, and from an emphasis on victimization and drudgery to an emphasis on strength and endurance; and to identify those qualities which have consistently characterized mountain women in literature.

Download Narrow Roads of Gene Land: Volume 1: Evolution of Social Behaviour PDF

Narrow Roads of Gene Land: Volume 1: Evolution of Social Behaviour

Author: W. D. Hamilton
Publsiher: Narrow Roads of Gene Land Vol.
Total Pages: 570
Release: 1996
Genre: Science
ISBN: 9780716745303
Rating: 4.7/5 (167 downloads)

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Vol. 1.

Download Embryonic and Molecular Studies on Wingless Protein in Patterning and Cellular Signaling PDF

Embryonic and Molecular Studies on Wingless Protein in Patterning and Cellular Signaling

Author: Peggy Pauline Vorwald
Total Pages: 213
Release: 2013
Rating: 4./5 ( downloads)

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Wnt/Wingless (Wg) signaling is one of the major molecular pathways regulating formation of the anterio-posterior (AP) axis in the developing embryo. Almost every organism in the animal kingdom requires Wnt signaling to establish the AP axis, the exception to this rule is the common fruit fly. This thesis will examine the role of Wnt/Wg in the early Drosophila embryo and show that while modern flies may not depend on posterior Wg expression, its expression is still regulated suggesting Wnt may play a role in refinement of the AP axis and likey had a more significant role prior to the divergence of the species. During Wnt signal transduction GSK3 phosphorylation of [beta]-Catenin is inhibited, however, it remained unclear how this inhibition occurred. This thesis reveals a novel mechanism of GSK3 inhibition by sequestration into multivesicular bodies (MVB). We show that Wnt signaling causes GSK3 to be relocalized inside MVBs where the enzyme can no longer interact with [beta]-Catenin to cause its degradation. We also show that many proteins, in addition to [beta]-Catenin, are also stabilized. We explore the identity of these proteins using stable isotope labeling by amino acids in cell culture (SILAC) and tandem mass-spectrometry analysis. Finally, we introduce a new Drosophila cell line, ML-DmBG3-c2, that could aide in our understanding of the role of vesicle trafficking in transduction of the Wnt/Wg signal. The work presented in this thesis contributed to the field of developmental biology and Wnt/Wg signaling by 1) highlighting the posterior expression of Wg in Drosophila embryo development and its potential for refinement of the A-P axis, 2) revealing the mechanism for GSK3 inhibition through sequestration into MVBs which leads to stabilization of many proteins which effect many cellular processes, and 3) identifying a novel cell line with great potential for investigating the role of endocytosis and Wnt signaling. While these studies offer some contribution, continued research into the of the role of Wnt in embryo development and mechanism of signal transduction will help to improve the treatments for birth defects and many types of cancers.

Download Wingless and Cursed PDF

Wingless and Cursed

Author: D. M. White
Total Pages: 240
Release: 2013-09-16
Genre: Juvenile Fiction
ISBN: 9781941253021
Rating: 4.9/5 (412 downloads)

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Alexander is the Alpha wolf of the Neuri werewolf tribe, set to destroy anything associated with the dreaded strigoi. Lea is a magnificent Fae -- or so she believed but she soon discovers she may not be after all. With Alexander, Lea's and basically the worlds fate is in the hands of the mated pair. They must act fast and not just on the revenge they so desperately need. Can their love save us all? As Lea and Alexander's souls hang in the balance they come to realize we are all a little Cursed. RECOMMENDED FOR 15+ gore, violence, some not appropriate for younger readers.

Download Endocytosis and Wingless Signalling PDF

Endocytosis and Wingless Signalling

Author: M. Gagliardi
Total Pages:
Release: 2012
Rating: 4./5 ( downloads)

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Wingless (Drosophila Wnt-1) is secreted glycoprotein that triggers an evolutionary conserved signal transduction pathway. The role of endocytosis in Wnt/Wingless signaling is not clearly understood and highly debated. In my thesis I explore the role that endocytosis/endocytic trafficking has on Wingless signalling activation and termination. In the canonical pathway Wingless binds to a member of the Frizzled family of seven-pass transmembrane receptor (Frizzled1 or Frizzled2) and to Arrow. Formation of this trimeric complex leads to the inactivation of the Armadillo degradation complex and translocation of Armadillo into the nucleus where it contributes to the activation of target genes. I show that internalization of the ligand-receptor complex is not required for signalling activation. I also show that Wingless has different effects on the trafficking route of its receptors: it induces the degradation of Frizzled2 and the recycling of Arrow. To identify post translational modifications that regulate Arrow trafficking I conducted an RNAi screen in Drosophila S2R+ cells for de-ubiquitylating enzymes (DUBs) and ubiquitin conjugating enzymes (E2) that modulate signalling. To carry out this screen, improvements on the current TOPFlash Wnt/Wingless signalling reporter were made. I also directly assessed the role of endocytic trafficking on signalling using a chemical inhibitor of endocytosis, Dynasore. I find that Dynasore inhibits signalling by causing a strong decrease in Armadillo levels. Future experiments will determine whether it is the stability or the rate of production of Armadillo that is affected.

Download Rebecca and the Changeling PDF

Rebecca and the Changeling

Author: Margaret Pearce
Publsiher: Writers Exchange E-Publishing
Total Pages: 41
Release: 2012-05
Genre: Juvenile Fiction
ISBN: 1921636912
Rating: 4.6/5 (369 downloads)

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When the fairy queen swaps her new baby for a mortal's new baby, her daughter Dewdrop feels sorry for the mortal family she watches all the time. She rescues and returns Willyum back to his human family. When the fairy queen discovers what she's done, she's so cross, she swaps Dewdrop's life with the mortal girl Rebecca's as punishment. But Dewdrop loves her new mortal family and all their adventures, and now Rebecca adores being a fairy. Everyone's happy, right? Everyone except the fairy queen... A fairy princess, bored with her existence, breaks a few rules, gets into mischief and ends up getting her wish never to be bored granted...but definitely not the way she expected! Flesch Reading Ease 81.7 Flesch-Kincaid Grade Level 4.4

Download Techniques in Molecular Systematics and Evolution PDF

Techniques in Molecular Systematics and Evolution

Author: Rob DeSalle
Publsiher: Birkhäuser
Total Pages: 410
Release: 2013-12-01
Genre: Science
ISBN: 3034881258
Rating: 4.8/5 (812 downloads)

Download Techniques in Molecular Systematics and Evolution Book in PDF, Epub and Kindle

The amount of information that can be obtained by using molecular techniques in evolution, systematics and ecology has increased exponentially over the last ten years. The need for more rapid and efficient methods of data acquisition and analysis is growing accordingly. This manual presents some of the most important techniques for data acquisition developed over the last years. The choice and justification of data analysis techniques is also an important and critical aspect of modern phylogenetic and evolutionary analysis and so a considerable part of this volume addresses this important subject. The book is mainly written for students and researchers from evolutionary biology in search for methods to acquire data, but also from molecular biology who might be looking for information on how data are analyzed in an evolutionary context. To aid the user, information on web-located sites is included wherever possible. Approaches that will push the amount of information which systematics will gather in the

Download Mededelingen Landbouwhogeschool, Wageningen PDF

Mededelingen Landbouwhogeschool, Wageningen

Author: Landbouwhogeschool Wageningen
Total Pages: 720
Release: 1983
Genre: Agriculture
Rating: 4./5 ( downloads)

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Download Wingless Flight PDF

Wingless Flight

Author: R. Dale Reed
Total Pages: 256
Release: 2005-01-01
Genre: Technology & Engineering
ISBN: 9781410221223
Rating: 4.4/5 (12 downloads)

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Wingless Flight tells the story of the most unusual flying machines ever flown, the lifting bodies. It is my story about my friends and colleagues who committed a significant part of their lives in the 1960s and 1970s to prove that the concept was a viable one for use in spacecraft of the future. This story, filled with drama and adventure, is about the twelve-year period from 1963 to 1975 in which eight different lifting-body configurations flew. It is appropriate for me to write the story, since I was the engineer who first presented the idea of flight-testing the concept to others at the NASA Flight Research Center. Over those twelve years, I experienced the story as it unfolded day by day at that remote NASA facility northeast of Los Angeles in the bleak Mojave Desert. Benefits from this effort immediately influenced the design and operational concepts of the winged NASA Shuttle Orbiter. However, the full benefits would not be realized until the 1990s when new spacecraft such as the X-33 and X-38 would fully employ the lifting-body concept. A lifting body is basically a wingless vehicle that flies due to the lift generated by the shape of its fuselage. Although both a lifting reentry vehicle and a ballistic capsule had been considered as options during the early stages of NASA's space program, NASA initially opted to go with the capsule. A number of individuals were not content to close the book on the lifting-body concept. Researchers including Alfred Eggers at the NASA Ames Research Center conducted early wind-tunnel experiments, finding that half of a rounded nose-cone shape that was flat on top and rounded on the bottom could generate a lift-to-drag ratio of about 1.5 to 1.Eggers' preliminary design sketch later resembled the basic M2 lifting-body design. At the NASA Langley Research Center, other researchers toyed with their own lifting-body shapes.